Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery

Schraga Schwartz; Nurit Gal-Mark; Nir Kfir; Ram Oren; Eddo Kim; Gil Ast

doi:10.1371/journal.pcbi.1000300

Loading metrics

Open Access

Peer-reviewed

Research Article

Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery

Schraga Schwartz,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Nurit Gal-Mark,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Nir Kfir,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Ram Oren,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Eddo Kim,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Gil Ast

* E-mail: gilast@post.tau.ac.il

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯

Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery

Schraga Schwartz,
Nurit Gal-Mark,
Nir Kfir,
Ram Oren,
Eddo Kim,
Gil Ast

Published: March 6, 2009
https://doi.org/10.1371/journal.pcbi.1000300

About the Authors

Schraga Schwartz

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Nurit Gal-Mark

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Nir Kfir

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Ram Oren

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Eddo Kim

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Gil Ast

* E-mail: gilast@post.tau.ac.il

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS NGM RO GA. Performed the experiments: SS. Analyzed the data: SS. Contributed reagents/materials/analysis tools: SS NGM NK EK. Wrote the paper: SS NGM NK RO GA.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Alu elements
Is the Subject Area "Alu elements" applicable to this article?

Thanks for your feedback.
Introns
Is the Subject Area "Introns" applicable to this article?

Thanks for your feedback.
Support vector machines
Is the Subject Area "Support vector machines" applicable to this article?

Thanks for your feedback.
Machine learning
Is the Subject Area "Machine learning" applicable to this article?

Thanks for your feedback.
Alternative splicing
Is the Subject Area "Alternative splicing" applicable to this article?

Thanks for your feedback.
RNA structure
Is the Subject Area "RNA structure" applicable to this article?

Thanks for your feedback.
Sequence alignment
Is the Subject Area "Sequence alignment" applicable to this article?

Thanks for your feedback.
Spliceosomes
Is the Subject Area "Spliceosomes" applicable to this article?

Thanks for your feedback.