About the Authors

Rui-Ru Ji

ruiruji@gmail.com

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Heshani de Silva

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Yisheng Jin

Affiliation Johnson Graduate School of Management, Cornell University, Ithaca, New York, United States of America

Robert E. Bruccoleri

Affiliation Congenomics, Glastonbury, Connecticut, United States of America

Jian Cao

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Aiqing He

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Wenjun Huang

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Paul S. Kayne

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Isaac M. Neuhaus

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Karl-Heinz Ott

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Becky Penhallow

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Mark I. Cockett

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Michael G. Neubauer

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Nathan O. Siemers

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Petra Ross-Macdonald

Affiliation Bristol-Myers Squibb Research and Development, Princeton, New Jersey, United States of America

Competing Interests

The authors are current and previous employees of Bristol-Myers Squibb, who is the manufacturer of dasatinib (one of the compounds included in the study).

Author Contributions

Performed the experiments: HdS JC AH WH BP. Analyzed the data: RRJ YJ KHO PRM. Contributed reagents/materials/analysis tools: RRJ REB PSK IMN MIC NOS. Wrote the paper: RRJ PRM. Developed the analytical methods described in the manuscript: RRJ. Designed the experiments: HdS. Revised the manuscript: YJ REB KHO NOS. Conceived transcriptional dose response concept: MGN.