About the Authors

Wesley C. Van Voorhis

Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

Wim G. J. Hol

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Peter J. Myler

peter.myler@sbri.org (PJM); Lstewart@decode.com (LJS)

Affiliations Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, Washington, United States of America

Lance J. Stewart

peter.myler@sbri.org (PJM); Lstewart@decode.com (LJS)

Affiliation deCODE biostructures, Bainbridge Island, Washington, United States of America

Competing Interests

Co-author Lance Stewart is an employee of deCODE biostructures, which developed the Fragments-of-Life library presented in Figure 1 and discussed in sections titled ‘Fragment-based drug discovery’ and ‘Targeting oligomeric enzymes’. Fragments-of-Life TM is a technology trademarked by deCODE biostructures and chemistry (http://www.decodechembio.com/Capabilities/StructuralBiology/FragmentsofLife.aspx).