Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local

Wee Siong Goh; Yuriy Orlov; Jingmei Li; Neil D. Clarke

doi:10.1371/journal.pcbi.1000649

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Open Access

Peer-reviewed

Research Article

Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local

Wee Siong Goh,

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore
⨯
Yuriy Orlov,

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore
⨯
Jingmei Li,

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore
⨯
Neil D. Clarke

* E-mail: clarken@gis.a-star.edu.sg

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore
⨯

Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local

Wee Siong Goh,
Yuriy Orlov,
Jingmei Li,
Neil D. Clarke

Published: January 22, 2010
https://doi.org/10.1371/journal.pcbi.1000649

About the Authors

Wee Siong Goh

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore

Yuriy Orlov

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore

Jingmei Li

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore

Neil D. Clarke

* E-mail: clarken@gis.a-star.edu.sg

Affiliation Computational and Systems Biology, Genome Institute of Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NDC. Performed the experiments: JL. Analyzed the data: WSG YO NDC. Wrote the paper: WSG NDC. Helped edit the paper: YO.

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Nucleosomes
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Nucleosome mapping
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Chromatin
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Genomics
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Transcription factors
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Binding analysis
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Sequence motif analysis
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Yeast
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