About the Authors

Phaedra Agius

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Aaron Arvey

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

William Chang

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

William Stafford Noble

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Christina Leslie

cleslie@cbio.mskcc.org

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: PA AA CL. Developed the kernel approach, carried out the computational experiments on the protein binding microarray data sets, assisted with analysis of the ChIP-seq data sets, and helped to supervise students working on the project : PA. Conceived of project and helped to design computational approach, supervised the research: CL. Carried out the computational experiments on the ChIP-seq data sets: AA. Carried out the yeast conservation analysis and helped to test the kernel approach on protein binding microarray data sets: WC. Helped to supervise the research and edit the manuscript: WSN.