Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks

Dan Siegal-Gaskins; Maria Katherine Mejia-Guerra; Gregory D. Smith; Erich Grotewold

doi:10.1371/journal.pcbi.1002039

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Open Access

Peer-reviewed

Research Article

Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks

Dan Siegal-Gaskins ,

* E-mail: dsg@mbi.osu.edu

Affiliations Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Maria Katherine Mejia-Guerra,

Affiliation Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Gregory D. Smith,

Affiliation Department of Applied Science, The College of William and Mary, Williamsburg, Virginia, United States of America
⨯
Erich Grotewold

Affiliation Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America
⨯

Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks

Dan Siegal-Gaskins,
Maria Katherine Mejia-Guerra,
Gregory D. Smith,
Erich Grotewold

Published: May 12, 2011
https://doi.org/10.1371/journal.pcbi.1002039

About the Authors

Dan Siegal-Gaskins

* E-mail: dsg@mbi.osu.edu

Affiliations Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America

Maria Katherine Mejia-Guerra

Affiliation Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America

Gregory D. Smith

Affiliation Department of Applied Science, The College of William and Mary, Williamsburg, Virginia, United States of America

Erich Grotewold

Affiliation Department of Molecular Genetics and Plant Biotechnology Center, The Ohio State University, Columbus, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DSG GDS EG. Performed the experiments: DSG MKMG GDS. Analyzed the data: DSG MKMG. Contributed reagents/materials/analysis tools: DSG GDS. Wrote the paper: DSG MKMG GDS EG.

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Protein interaction networks
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Genetic networks
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Network analysis
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Protein-protein interactions
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Dimers
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Saccharomyces cerevisiae
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Stoichiometry
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Transcription factors
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