About the Authors

Lan K. Nguyen

Contributed equally to this work with: Lan K. Nguyen, Javier Muñoz-García

Affiliation Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Javier Muñoz-García

Contributed equally to this work with: Lan K. Nguyen, Javier Muñoz-García

Affiliation Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Helene Maccario

Affiliation Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Aaron Ciechanover

Affiliation Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel

Walter Kolch

Affiliation Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Boris N. Kholodenko

boris.kholodenko@ucd.ie

Affiliations Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LKN JMG HM AC WK BNK. Performed the experiments: LKN JMG HM BNK. Analyzed the data: LKN JMG HM BNK. Contributed reagents/materials/analysis tools: LKN JMG HM BNK. Wrote the paper: LKN JMG AC WK BNK.