About the Authors
- Jon D. Duke
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Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang
Affiliation Regenstrief Institute, Indianapolis, Indiana, United States of America
- Xu Han
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Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang
Affiliations Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Zhiping Wang
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Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang
Affiliations Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Abhinita Subhadarshini
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Affiliation Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Shreyas D. Karnik
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Affiliation Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Xiaochun Li
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Affiliation Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Stephen D. Hall
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Affiliation Eli Lilly Inc., Indianapolis, Indiana, United States of America
- Yan Jin
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Affiliation Eli Lilly Inc., Indianapolis, Indiana, United States of America
- J. Thomas Callaghan
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Affiliation Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Marcus J. Overhage
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Affiliation Siemens, Malvern, Pennsylvania, United States of America
- David A. Flockhart
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Affiliations Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America
- R. Matthew Strother
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Affiliations Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Sara K. Quinney
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Affiliations Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America, Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America
- Lang Li
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* E-mail: lali@iupui.edu
Affiliations Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: JDD XL SDH YJ JTC MJO DAF RMS SKQ LL. Performed the experiments: JDD XH ZW AS SDK LL. Analyzed the data: XH ZW LL. Wrote the paper: JDD XL SKQ LL. Proposed the whole picture of the DDI research project: LL. Guided all the data analyses: LL. Finalized the writing of the paper: LL. Contributed to the pharmaco-epidemiology design: JDD XL RMS SKQ. Contributed to the interpretation of the DDI results: JDD RMS SKQ. Performed the DDI/myopathy association analysis: XH. Provided the mechanistic interpretation of DDIs: SDH. Curated the data: XH AS SDK. Performed the EMR data mapping, data extraction and merging, and analyzable data preparation: ZW. Performed the literature mining: AS SDK. Contributed to the initial ideas formulation: SDH YJ JTC MJO. Contributed to the analysis strategy: XL.