Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Andrei Zinovyev; Inna Kuperstein; Emmanuel Barillot; Wolf-Dietrich Heyer

doi:10.1371/journal.pcbi.1003016

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Peer-reviewed

Research Article

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Andrei Zinovyev ,

Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

* E-mail: Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France
⨯
Inna Kuperstein ,

Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France
⨯
Emmanuel Barillot,

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France
⨯
Wolf-Dietrich Heyer

* E-mail: Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

Affiliation Departments of Microbiology & Molecular Genetics and of Molecular & Cellular Biology, University of California, Davis, Davis, California, United States of America
⨯

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Andrei Zinovyev,
Inna Kuperstein,
Emmanuel Barillot,
Wolf-Dietrich Heyer

Published: April 4, 2013
https://doi.org/10.1371/journal.pcbi.1003016

About the Authors

Andrei Zinovyev

Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

* E-mail: Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

Inna Kuperstein

Contributed equally to this work with: Andrei Zinovyev, Inna Kuperstein

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

Emmanuel Barillot

Affiliations Institut Curie, Paris, France, INSERM, U900, Paris, France, Mines ParisTech, Fontainebleau, France

Wolf-Dietrich Heyer

* E-mail: Andrei.Zinovyev@curie.fr (AZ); wdheyer@ucdavis.edu (WDH)

Affiliation Departments of Microbiology & Molecular Genetics and of Molecular & Cellular Biology, University of California, Davis, Davis, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AZ IK WDH. Performed the experiments: AZ. Analyzed the data: AZ IK EB WDH. Wrote the paper: AZ IK EB WDH.

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DNA repair
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Metabolic pathways
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Genetic interactions
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DNA damage
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Genetics
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Yeast
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