About the Authors

Evan J. Molinelli

Contributed equally to this work with: Evan J. Molinelli, Anil Korkut, Weiqing Wang

Affiliations Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Tri-Institutional Program for Computational Biology and Medicine, Weill Cornell Medical College, New York, New York, United States of America

Anil Korkut

Contributed equally to this work with: Evan J. Molinelli, Anil Korkut, Weiqing Wang

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Weiqing Wang

Contributed equally to this work with: Evan J. Molinelli, Anil Korkut, Weiqing Wang

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Martin L. Miller

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Nicholas P. Gauthier

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Xiaohong Jing

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Poorvi Kaushik

Affiliations Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Tri-Institutional Program for Computational Biology and Medicine, Weill Cornell Medical College, New York, New York, United States of America

Qin He

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Gordon Mills

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

David B. Solit

Affiliations Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Christine A. Pratilas

Affiliations Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Martin Weigt

Affiliation Laboratoire de Génomique des Microorganismes, Université Pierre et Marie Curie, Paris, France

Alfredo Braunstein

Affiliation Politecnico di Torino and Human Genetics Foundation, HuGeF, Torino, Italy

Andrea Pagnani

Affiliation Politecnico di Torino and Human Genetics Foundation, HuGeF, Torino, Italy

Riccardo Zecchina

Affiliation Politecnico di Torino and Human Genetics Foundation, HuGeF, Torino, Italy

Chris Sander

perturbation-biology@cbio.mskcc.org

Affiliation Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EJM AK WW CS . Performed the experiments: WW MLM NPG XJ PK QH. Analyzed the data: EJM AK. Contributed reagents/materials/analysis tools: GM DBS CAP. Wrote the paper: EJM AK WW AP CS. Reverse Phase Protein Array Platform: GM. Cell lines: DBS CAP. Development and optimization of code: EJM AK AB AP. Statistical physics: MW AB AP RZ. Network modeling with synthetic data: EJM. Network modeling with biological data: AK.