A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Daniel H Haft; Jeremy Selengut; Emmanuel F Mongodin; Karen E Nelson

doi:10.1371/journal.pcbi.0010060

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Open Access

Peer-reviewed

Research Article

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Daniel H Haft ,

*To whom correspondence should be addressed. E-mail: haft@tigr.org

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America
⨯
Jeremy Selengut,

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America
⨯
Emmanuel F Mongodin,

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America
⨯
Karen E Nelson

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America
⨯

A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

Daniel H Haft,
Jeremy Selengut,
Emmanuel F Mongodin,
Karen E Nelson

Published: November 11, 2005
https://doi.org/10.1371/journal.pcbi.0010060

About the Authors

Daniel H Haft

*To whom correspondence should be addressed. E-mail: haft@tigr.org

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America

Jeremy Selengut

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America

Emmanuel F Mongodin

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America

Karen E Nelson

Affiliation The Institute for Genomic Research, Rockville, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DHH and JS conceived and designed the experiments. DHH, JS, and EFM performed the experiments. DHH, JS, EFM, and KEN analyzed the data. DHH, JS, EFM, and KEN contributed reagents/materials/analysis tools. DHH, JS, EFM, and KEN wrote the paper.

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Genetic loci
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CRISPRs
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Genomics
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Hidden Markov models
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Bacterial genomics
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Sequence alignment
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Phylogenetic analysis
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Phylogenetics
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