About the Authors

Thomas LaFramboise

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Barbara A Weir

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Xiaojun Zhao

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Rameen Beroukhim

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Cheng Li

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America

David Harrington

Affiliation Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, United States of America

William R Sellers

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Matthew Meyerson

To whom correspondence should be addressed. E-mail: matthew_meyerson@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America , The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TL and BAW conceived and designed the experiments. BAW and XZ performed the experiments. TL developed the statistical procedure and analyzed the data. RB contributed reagents/materials/analysis tools. CL, DH, and WRS advised on the project. MM supervised the project. TL and BAW wrote the paper.