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Research Article

Long-Range Periodic Patterns in Microbial Genomes Indicate Significant Multi-Scale Chromosomal Organization

  • Timothy E Allen,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

    ¤a Current address: Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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  • Nathan D Price,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

    ¤b Current address: The Institute for Systems Biology, Seattle, Washington, United States of America

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  • Andrew R Joyce,

    Affiliation: Bioinformatics Program, University of California San Diego, La Jolla, California, United States of America

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  • Bernhard Ø Palsson mail

    To whom correspondence should be addressed. E-mail: palsson@ucsd.edu

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Published: January 13, 2006
  • DOI: 10.1371/journal.pcbi.0020002

About the Authors

Timothy E Allen, Nathan D Price, Bernhard Ø Palsson
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America
Andrew R Joyce
Bioinformatics Program, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: palsson@ucsd.edu

Competing Interests

BØP serves on the Scientific Advisory Board of Genomatica.

Author Contributions

TEA and BØP conceived and designed the experiments. TEA performed the experiments. TEA, NDP, and ARJ analyzed the data. TEA and ARJ contributed reagents/materials/analysis tools. TEA, NDP, ARJ, and BØP wrote the paper.