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Research Article

Identification and Classification of Conserved RNA Secondary Structures in the Human Genome

  • Jakob Skou Pedersen mail,

    To whom correspondence should be addressed. E-mail: jsp@soe.ucsc.edu

    Affiliation: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Gill Bejerano,

    Affiliation: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Adam Siepel,

    Affiliation: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

    ¤ Current address: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Kate Rosenbloom,

    Affiliation: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Kerstin Lindblad-Toh,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Eric S Lander,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Jim Kent,

    Affiliation: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Webb Miller,

    Affiliation: Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • David Haussler

    Affiliations: Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Published: April 21, 2006
  • DOI: 10.1371/journal.pcbi.0020033

About the Authors

Jakob Skou Pedersen, Gill Bejerano, Adam Siepel, Kate Rosenbloom, Jim Kent, David Haussler
Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America
Kerstin Lindblad-Toh, Eric S Lander
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Webb Miller
Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania, United States of America
David Haussler
Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Corresponding Author

Email: jsp@soe.ucsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JSP, GB, and DH conceived and designed the experiments. JSP and GB performed the experiments. JSP analyzed the data. JSP, AS, KR, KLT, ESL, JK, and WM contributed reagents/materials/analysis tools. JSP and DH wrote the paper.