About the Authors

Anthony A Philippakis

Contributed equally to this work with: Anthony A Philippakis, Brian W Busser

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Harvard/MIT Division of Health Sciences and Technology (HST), Harvard Medical School, Boston, Massachusetts, United States of America , Harvard University Graduate Biophysics Program, Harvard Medical School, Boston, Massachusetts, United States of America

Brian W Busser

Contributed equally to this work with: Anthony A Philippakis, Brian W Busser

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Stephen S Gisselbrecht

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Fangxue Sherry He

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Harvard/MIT Division of Health Sciences and Technology (HST), Harvard Medical School, Boston, Massachusetts, United States of America

Beatriz Estrada

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Alan M Michelson

To whom correspondence should be addressed. E-mail: michelson@receptor.med.harvard.edu (AMM), mlbulyk@receptor.med.harvard.edu (MLB)

Affiliation Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Martha L Bulyk

To whom correspondence should be addressed. E-mail: michelson@receptor.med.harvard.edu (AMM), mlbulyk@receptor.med.harvard.edu (MLB)

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America , Harvard/MIT Division of Health Sciences and Technology (HST), Harvard Medical School, Boston, Massachusetts, United States of America , Harvard University Graduate Biophysics Program, Harvard Medical School, Boston, Massachusetts, United States of America , Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AAP, BWB, SSG, AMM, and MLB conceived and designed the experiments. AAP, BWB, and SSG performed the experiments. AAP, BWB, and SSG analyzed the data. FSH and BE contributed reagents/materials/analysis tools. AAP, BWB, SSG, AMM, and MLB wrote the paper.