About the Authors

Feng Ding

Affiliation Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Nikolay V Dokholyan

To whom correspondence should be addressed. E-mail: dokh@med.unc.edu

Affiliation Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

FD and NVD conceived and designed the experiments, performed the experiments, analyzed the data, and wrote the paper.