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Research Article

Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes

  • Chad Haynes,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Christopher J Oldfield,

    Affiliation: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Fei Ji,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Niels Klitgord,

    Affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Michael E Cusick,

    Affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Predrag Radivojac,

    Affiliation: Indiana University School of Informatics, Bloomington, Indiana, United States of America

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  • Vladimir N Uversky,

    Affiliations: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia

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  • Marc Vidal,

    Affiliations: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lilia M Iakoucheva mail

    To whom correspondence should be addressed. E-mail: lilia@rockefeller.edu

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Published: August 04, 2006
  • DOI: 10.1371/journal.pcbi.0020100

About the Authors

Chad Haynes, Fei Ji, Lilia M Iakoucheva
Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America
Christopher J Oldfield, Vladimir N Uversky
Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Niels Klitgord, Michael E Cusick, Marc Vidal
Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Marc Vidal
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Predrag Radivojac
Indiana University School of Informatics, Bloomington, Indiana, United States of America
Vladimir N Uversky
Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia

Corresponding Author

Email: lilia@rockefeller.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CH, CJO, MEC, PR, VNU, MV, and LMI conceived and designed the experiments. CH, CJO, FJ, NK, and LMI performed the experiments. CH, CJO, FJ, and LMI analyzed the data. CH, FJ, NK, MEC, and PR, contributed reagents/materials/analysis tools. CJO, MEC, VNU, MV, and LMI wrote the paper.