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Research Article

Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems

  • Erwin P Gianchandani equal contributor,

    equal contributor Contributed equally to this work with: Erwin P Gianchandani, Jason A Papin

    Affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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  • Jason A Papin equal contributor mail,

    equal contributor Contributed equally to this work with: Erwin P Gianchandani, Jason A Papin

    To whom correspondence should be addressed. E-mail: papin@virginia.edu

    Affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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  • Nathan D Price,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

    ¤ Current address: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Andrew R Joyce,

    Affiliation: Bioinformatics Program, University of California San Diego, La Jolla, California, United States of America

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  • Bernhard O Palsson

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

    X
  • Published: August 11, 2006
  • DOI: 10.1371/journal.pcbi.0020101

About the Authors

Erwin P Gianchandani, Jason A Papin
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America
Nathan D Price, Bernhard O Palsson
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America
Andrew R Joyce
Bioinformatics Program, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: papin@virginia.edu

Competing Interests

BOP is on the scientific advisory board of Genomatica, and BOP and the University of California San Diego (UCSD) have a financial interest in Genomatica. Although NIH grant GM68837 has been identified for conflict of interest management based on the overall scope of the project and its potential to benefit to Genomatica, the research findings included in this publication may not necessarily directly relate to the interests of Genomatica.

Author Contributions

EPG, JAP, NDP, ARJ, and BOP conceived and designed the experiments. EPG, JAP, NDP, and ARJ performed the experiments. EPG, JAP, NDP, ARJ, and BOP analyzed the data. EPG, JAP, NDP, ARJ, and BOP wrote the paper.