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Research Article

Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila

  • Alan M Moses,

    Affiliation: Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America

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  • Daniel A Pollard,

    Affiliation: Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America

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  • David A Nix,

    Affiliation: Department of Genome Sciences, Genomics Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America

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  • Venky N Iyer,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Xiao-Yong Li,

    Affiliation: Department of Genome Sciences, Genomics Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America

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  • Mark D Biggin,

    Affiliation: Department of Genome Sciences, Genomics Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America

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  • Michael B Eisen mail

    To whom correspondence should be addressed. E-mail: mbeisen@lbl.gov

    Affiliations: Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America, Department of Genome Sciences, Genomics Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Integrative Genomics, University of California Berkeley, Berkeley, California, United States of America

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  • Published: October 13, 2006
  • DOI: 10.1371/journal.pcbi.0020130

About the Authors

Alan M Moses, Daniel A Pollard, Michael B Eisen
Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America
David A Nix, Xiao-Yong Li, Mark D Biggin, Michael B Eisen
Department of Genome Sciences, Genomics Division, Ernest Orlando Lawrence Berkeley National Lab, Berkeley, California, United States of America
Venky N Iyer, Michael B Eisen
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
Michael B Eisen
Center for Integrative Genomics, University of California Berkeley, Berkeley, California, United States of America

Corresponding Author

Email: mbeisen@lbl.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AMM and MBE conceived and designed the experiments. AMM, DAP, and XYL performed the experiments. AMM and DAP analyzed the data. AMM, DAP, DAN, VNI, XYL, and MDB contributed reagents/materials/analysis tools. AMM, MBE, DAP, and DAN wrote the paper.