Advertisement
Research Article

Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors

  • Xiaolin Cheng mail,

    To whom correspondence should be addressed. E-mail: xcheng@mccammon.ucsd.edu

    Affiliations: Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America, NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

    X
  • Hailong Wang,

    Affiliation: Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

    X
  • Barry Grant,

    Affiliation: NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

    X
  • Steven M Sine,

    Affiliation: Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

    X
  • J. Andrew McCammon

    Affiliations: Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America, NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

    X
  • Published: September 29, 2006
  • DOI: 10.1371/journal.pcbi.0020134

About the Authors

Xiaolin Cheng, J. Andrew McCammon
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America
Xiaolin Cheng, Barry Grant, J. Andrew McCammon
NSF Center for Theoretical Biophysics, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
Hailong Wang, Steven M Sine
Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
J. Andrew McCammon
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: xcheng@mccammon.ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XC, HW, SMS, and JAM conceived and designed the experiments. XC and HW performed the experiments. XC and HW analyzed the data. XC, BG, SMS, and JAM wrote the paper.