The Role of Compensatory Mutations in the Emergence of Drug Resistance

Andreas Handel; Roland R Regoes; Rustom Antia

doi:10.1371/journal.pcbi.0020137

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Open Access

Peer-reviewed

Research Article

The Role of Compensatory Mutations in the Emergence of Drug Resistance

Andreas Handel ,

*To whom correspondence should be addressed. E-mail: ahandel@emory.edu

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America
⨯
Roland R Regoes,

¤ Current address: Theoretical Biology, Swiss Federal Institute of Technology, Zurich, Switzerland

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America
⨯
Rustom Antia

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America
⨯

The Role of Compensatory Mutations in the Emergence of Drug Resistance

Andreas Handel,
Roland R Regoes,
Rustom Antia

Published: October 13, 2006
https://doi.org/10.1371/journal.pcbi.0020137

About the Authors

Andreas Handel

*To whom correspondence should be addressed. E-mail: ahandel@emory.edu

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America

Roland R Regoes

¤ Current address: Theoretical Biology, Swiss Federal Institute of Technology, Zurich, Switzerland

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America

Rustom Antia

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AH, RRR, and RA conceived and designed the study. AH performed the analysis and simulations and analyzed the data. RRR contributed analysis tools. AH, RRR, and RA wrote the paper.

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