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Research Article

The Transcriptional Regulator CBP Has Defined Spatial Associations within Interphase Nuclei

  • Kirk J McManus,

    Affiliation: Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada

    ¤ Current address: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

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  • David A Stephens,

    Affiliation: Department of Mathematics, Imperial College London, London, United Kingdom

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  • Niall M Adams,

    Affiliation: Department of Mathematics, Imperial College London, London, United Kingdom

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  • Suhail A Islam,

    Affiliation: Division of Molecular Biosciences, Imperial College London, London, United Kingdom

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  • Paul S Freemont mail,

    To whom correspondence should be addressed. E-mail: p.freemont@imperial.ac.uk (PSF); michaelh@cancerboard.ab.ca (MJH)

    Affiliation: Division of Molecular Biosciences, Imperial College London, London, United Kingdom

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  • Michael J Hendzel mail

    To whom correspondence should be addressed. E-mail: p.freemont@imperial.ac.uk (PSF); michaelh@cancerboard.ab.ca (MJH)

    Affiliation: Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada

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  • Published: October 20, 2006
  • DOI: 10.1371/journal.pcbi.0020139

About the Authors

Kirk J McManus, Michael J Hendzel
Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
David A Stephens, Niall M Adams
Department of Mathematics, Imperial College London, London, United Kingdom
Suhail A Islam, Paul S Freemont
Division of Molecular Biosciences, Imperial College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KJM, DAS, PSF, and MJH conceived and designed the experiments. KJM performed the experiments. KJM, NMA, and SAI analyzed the data. KJM, DAS, NMA, SAI, PSF, and MJH wrote the paper.