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Research Article

Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms

  • Kai Xia equal contributor,

    equal contributor Contributed equally to this work with: Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Huiling Xue equal contributor,

    equal contributor Contributed equally to this work with: Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

    X
  • Dong Dong equal contributor,

    equal contributor Contributed equally to this work with: Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

    X
  • Shanshan Zhu equal contributor,

    equal contributor Contributed equally to this work with: Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

    X
  • Jiamu Wang,

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

    X
  • Qingpeng Zhang,

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

    X
  • Lei Hou,

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Hua Chen,

    Affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China

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  • Ran Tao,

    Affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China

    X
  • Zheng Huang,

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Zheng Fu,

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Ye-Guang Chen,

    Affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China

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  • Jing-Dong J Han mail

    To whom correspondence should be addressed. E-mail: jdhan@genetics.ac.cn

    Affiliation: The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Published: November 24, 2006
  • DOI: 10.1371/journal.pcbi.0020145

About the Authors

Kai Xia, Huiling Xue, Dong Dong, Shanshan Zhu, Jiamu Wang, Qingpeng Zhang, Lei Hou, Zheng Huang, Zheng Fu, Jing-Dong J Han
The Chinese Academy of Sciences Key Laboratory of Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China
Hua Chen, Ran Tao, Ye-Guang Chen
The State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China

Corresponding Author

Email: jdhan@genetics.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JDJH conceived and directed the project and designed the analyses. KX, HX, DD, SZ, QZ, and LH performed the analyses. ZF contributed materials and analysis tools. YGC and JDJH wrote the paper. KX, HX, DD, SZ, JW, HC, RT, and ZH annotated the interaction directions according to the literature.