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Research Article

Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set

  • Clive H Glover,

    Affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michael Marin,

    Affiliations: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

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  • Connie J Eaves,

    Affiliations: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Cheryl D Helgason,

    Affiliations: Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada, Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • James M Piret,

    Affiliations: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia, Canada

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  • Jennifer Bryan mail

    To whom correspondence should be addressed. E-mail: jenny@stat.ubc.ca

    Affiliations: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: November 24, 2006
  • DOI: 10.1371/journal.pcbi.0020158

About the Authors

Clive H Glover, Michael Marin, James M Piret, Jennifer Bryan
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
Michael Marin, Jennifer Bryan
Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada
Connie J Eaves
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Connie J Eaves
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Cheryl D Helgason
Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
Cheryl D Helgason
Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
James M Piret
Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: jenny@stat.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CHG, CJE, CDH, and JMP conceived and designed the experiments. CHG and CDH performed the experiments. CHG, MM, and JB analyzed the data. CDH contributed reagents/materials/analysis tools. CHG, CJE, JMP, and JB wrote the paper.