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Research Article

Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens

  • Jeroen de Ridder,

    Affiliations: Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Delft University of Technology, Delft, The Netherlands, Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Anthony Uren,

    Affiliation: Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Jaap Kool,

    Affiliation: Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Marcel Reinders mail,

    To whom correspondence should be addressed. E-mail: m.j.t.reinders@tudelft.nl (MR); l.f.a.wessels@tudelft.nl (LW)

    Affiliation: Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Delft University of Technology, Delft, The Netherlands

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  • Lodewyk Wessels mail

    To whom correspondence should be addressed. E-mail: m.j.t.reinders@tudelft.nl (MR); l.f.a.wessels@tudelft.nl (LW)

    Affiliations: Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Delft University of Technology, Delft, The Netherlands, Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Published: December 08, 2006
  • DOI: 10.1371/journal.pcbi.0020166

About the Authors

Jeroen de Ridder, Marcel Reinders, Lodewyk Wessels
Information and Communication Theory Group, Faculty of Electrical Engineering, Mathematics, and Computer Science, Delft University of Technology, Delft, The Netherlands
Jeroen de Ridder, Lodewyk Wessels
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Anthony Uren, Jaap Kool
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JdR, MR, and LW conceived and designed the experiments. JdR performed the experiments. JdR, AU, and JK analyzed the data. JdR wrote the paper.