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Research Article

Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling

  • Tamara L Kinzer-Ursem,

    Affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

    ¤ Current address: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Jennifer J Linderman mail

    To whom correspondence should be addressed. E-mail: linderma@umich.edu

    Affiliations: Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: January 12, 2007
  • DOI: 10.1371/journal.pcbi.0030006

About the Authors

Tamara L Kinzer-Ursem, Jennifer J Linderman
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
Jennifer J Linderman
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: linderma@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TLKU conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, and wrote the paper. JJL was the principal investigator, and analyzed data as well as wrote the paper.