Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology

Stefano Ciliberti; Olivier C Martin; Andreas Wagner

doi:10.1371/journal.pcbi.0030015

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Peer-reviewed

Research Article

Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology

Stefano Ciliberti ,

Contributed equally to this work with: Stefano Ciliberti, Olivier C Martin

Affiliations Laboratoire de Physique Théoique et Modèles Statistiques, Universite Paris-Sud, Orsay, France , Centre National de la Recherche Scientifique, Universite Paris-Sud, Orsay, France
⨯
Olivier C Martin ,

Contributed equally to this work with: Stefano Ciliberti, Olivier C Martin

Affiliations Laboratoire de Physique Théoique et Modèles Statistiques, Universite Paris-Sud, Orsay, France , Centre National de la Recherche Scientifique, Universite Paris-Sud, Orsay, France , Laboratoire de Genetique Vegetale du Moulon, Universite Paris-Sud, Gif-sur-Yvette, France , L'Institut National de la Recherche Agronomique, Universite Paris-Sud, Gif-sur-Yvette , Centre National de la Recherche Scientifique, Universite Paris-Sud, Gif-sur-Yvette, France
⨯
Andreas Wagner

*To whom correspondence should be addressed. E-mail: wagnera@unm.edu

Affiliation Department of Biochemistry, University of Zurich, Switzerland
⨯

Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology

Stefano Ciliberti,
Olivier C Martin,
Andreas Wagner

Published: February 2, 2007
https://doi.org/10.1371/journal.pcbi.0030015

About the Authors

Stefano Ciliberti

Contributed equally to this work with: Stefano Ciliberti, Olivier C Martin

Affiliations Laboratoire de Physique Théoique et Modèles Statistiques, Universite Paris-Sud, Orsay, France , Centre National de la Recherche Scientifique, Universite Paris-Sud, Orsay, France

Olivier C Martin

Contributed equally to this work with: Stefano Ciliberti, Olivier C Martin

Affiliations Laboratoire de Physique Théoique et Modèles Statistiques, Universite Paris-Sud, Orsay, France , Centre National de la Recherche Scientifique, Universite Paris-Sud, Orsay, France , Laboratoire de Genetique Vegetale du Moulon, Universite Paris-Sud, Gif-sur-Yvette, France , L'Institut National de la Recherche Agronomique, Universite Paris-Sud, Gif-sur-Yvette , Centre National de la Recherche Scientifique, Universite Paris-Sud, Gif-sur-Yvette, France

Andreas Wagner

*To whom correspondence should be addressed. E-mail: wagnera@unm.edu

Affiliation Department of Biochemistry, University of Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SC, OCM, and AW conceived and designed the experiments and analyzed the data. SC and OCM performed the experiments. OCM and AW wrote the paper.

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Genetic networks
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Gene expression
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Gene regulation
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Transcriptional control
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Gene regulatory networks
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Drug interactions
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Natural selection
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Monte Carlo method
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