Advertisement
Research Article

Functional Impact of Missense Variants in BRCA1 Predicted by Supervised Learning

  • Rachel Karchin mail,

    To whom correspondence should be addressed. E-mail: karchin@karchinlab.org (RK); sali@salilab.org (AS)

    Affiliations: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Institute of Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Alvaro N. A Monteiro,

    Affiliation: Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

    X
  • Sean V Tavtigian,

    Affiliation: International Agency for Research on Cancer, Lyon, France

    X
  • Marcelo A Carvalho,

    Affiliation: Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

    X
  • Andrej Sali mail

    To whom correspondence should be addressed. E-mail: karchin@karchinlab.org (RK); sali@salilab.org (AS)

    Affiliations: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: February 16, 2007
  • DOI: 10.1371/journal.pcbi.0030026

About the Authors

Rachel Karchin
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America
Rachel Karchin
Institute of Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
Alvaro N. A Monteiro, Marcelo A Carvalho
Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
Sean V Tavtigian
International Agency for Research on Cancer, Lyon, France
Andrej Sali
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Andrej Sali
California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RK, ANAM, MAC, and AS conceived and designed the experiments. RK and MAC performed the experiments. RK and ANAM analyzed the data. RK, ANAM, and SVT contributed reagents/materials/analysis tools. RK, ANAM, and AS wrote the paper.