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Research Article

PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

  • Xudong Dai mail,

    To whom correspondence should be addressed. E-mail: xudong_dai@merck.com (XD); yudong_he@merck.com (YDH)

    Affiliation: Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Angus T. De Souza,

    Affiliation: Preclinical Molecular Profiling, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Hongyue Dai,

    Affiliation: Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • David L Lewis,

    Affiliation: Mirus Bio Corporation, Madison, Wisconsin, United States of America

    X
  • Chang-kyu Lee,

    Affiliation: Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Andy G Spencer,

    Affiliation: Mirus Bio Corporation, Madison, Wisconsin, United States of America

    X
  • Hans Herweijer,

    Affiliation: Mirus Bio Corporation, Madison, Wisconsin, United States of America

    X
  • Jim E Hagstrom,

    Affiliation: Mirus Bio Corporation, Madison, Wisconsin, United States of America

    X
  • Peter S Linsley,

    Affiliation: Cancer Biology, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Douglas E Bassett,

    Affiliation: Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Roger G Ulrich,

    Affiliation: Preclinical Molecular Profiling, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Yudong D He mail

    To whom correspondence should be addressed. E-mail: xudong_dai@merck.com (XD); yudong_he@merck.com (YDH)

    Affiliation: Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Published: March 02, 2007
  • DOI: 10.1371/journal.pcbi.0030030

About the Authors

Xudong Dai, Hongyue Dai, Chang-kyu Lee, Douglas E Bassett, Yudong D He
Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
Angus T. De Souza, Roger G Ulrich
Preclinical Molecular Profiling, Rosetta Inpharmatics, Seattle, Washington, United States of America
David L Lewis, Andy G Spencer, Hans Herweijer, Jim E Hagstrom
Mirus Bio Corporation, Madison, Wisconsin, United States of America
Peter S Linsley
Cancer Biology, Rosetta Inpharmatics, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors are employees of Merck (XD, ATDS, HD, CKL, PSL, DEB, RGU, and YDH) or Mirus Bio (DLL, AGS, HH, and JEH).

Author Contributions

XD, ATDS, DLL, JEH, PSL, DEB, RGU, and YDH conceived and designed the experiments. Mirus colleagues performed the siRNA experiments, and Rosetta colleagues performed the profiling experiments at its Gene Expression Laboratory. XD, ATDS, CKL, PLS, and YDH analyzed the data. AGS, HH, HD, and CKL contributed reagents/materials/tools. XD wrote the paper.