About the Authors
- Xudong Dai
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*To whom correspondence should be addressed. E-mail: xudong_dai@merck.com (XD); yudong_he@merck.com (YDH)
Affiliation Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Angus T. De Souza
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Affiliation Preclinical Molecular Profiling, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Hongyue Dai
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Affiliation Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
- David L Lewis
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Affiliation Mirus Bio Corporation, Madison, Wisconsin, United States of America
- Chang-kyu Lee
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Affiliation Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Andy G Spencer
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Affiliation Mirus Bio Corporation, Madison, Wisconsin, United States of America
- Hans Herweijer
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Affiliation Mirus Bio Corporation, Madison, Wisconsin, United States of America
- Jim E Hagstrom
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Affiliation Mirus Bio Corporation, Madison, Wisconsin, United States of America
- Peter S Linsley
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Affiliation Cancer Biology, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Douglas E Bassett
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Affiliation Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Roger G Ulrich
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Affiliation Preclinical Molecular Profiling, Rosetta Inpharmatics, Seattle, Washington, United States of America
- Yudong D He
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*To whom correspondence should be addressed. E-mail: xudong_dai@merck.com (XD); yudong_he@merck.com (YDH)
Affiliation Informatics, Rosetta Inpharmatics, Seattle, Washington, United States of America
Competing Interests
The authors are employees of Merck (XD, ATDS, HD, CKL, PSL, DEB, RGU, and YDH) or Mirus Bio (DLL, AGS, HH, and JEH).
Author Contributions
XD, ATDS, DLL, JEH, PSL, DEB, RGU, and YDH conceived and designed the experiments. Mirus colleagues performed the siRNA experiments, and Rosetta colleagues performed the profiling experiments at its Gene Expression Laboratory. XD, ATDS, CKL, PLS, and YDH analyzed the data. AGS, HH, HD, and CKL contributed reagents/materials/tools. XD wrote the paper.