About the Authors

David Talavera

Contributed equally to this work with: David Talavera, Christine Vogel

Affiliations Molecular Modeling and Bioinformatics Unit, Parc Científic de Barcelona, Barcelona, Spain , Protein Structure and Modelling Node, Instituto Nacional de Bioinfomática, Genoma España, Parc Científic de Barcelona, Barcelona, Spain

Christine Vogel

Contributed equally to this work with: David Talavera, Christine Vogel

To whom correspondence should be addressed. E-mail: xavier@mmb.pcb.ub.es (XdlC); cvogel@mail.utexas.edu (CV)

Affiliations Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom , Institute for Cellular and Molecular Biology, University of Texas Austin, Austin, Texas, United States of America

Modesto Orozco

Affiliations Molecular Modeling and Bioinformatics Unit, Parc Científic de Barcelona, Barcelona, Spain , Protein Structure and Modelling Node, Instituto Nacional de Bioinfomática, Genoma España, Parc Científic de Barcelona, Barcelona, Spain , Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain , Institut per a la Recerca i Estudis Avançats (IRCA), Barcelona, Spain

Sarah A Teichmann

Affiliation Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

Xavier de la Cruz

To whom correspondence should be addressed. E-mail: xavier@mmb.pcb.ub.es (XdlC); cvogel@mail.utexas.edu (CV)

Affiliations Molecular Modeling and Bioinformatics Unit, Parc Científic de Barcelona, Barcelona, Spain , Protein Structure and Modelling Node, Instituto Nacional de Bioinfomática, Genoma España, Parc Científic de Barcelona, Barcelona, Spain , Computational Biology Program, Barcelona Supercomputing Center, Barcelona, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CV, SAT, and XdlC conceived and designed the experiments and wrote the paper. DT, CV, and MO performed the experiments. DT, CV, MO, SAT, and XdlC analyzed the data.