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Research Article

Modeling Networks of Coupled Enzymatic Reactions Using the Total Quasi-Steady State Approximation

  • Andrea Ciliberto mail,

    To whom correspondence should be addressed. E-mail: andrea.ciliberto@ifom-ieo-campus.it

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Fabrizio Capuani,

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • John J Tyson

    Affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Published: March 16, 2007
  • DOI: 10.1371/journal.pcbi.0030045

About the Authors

Andrea Ciliberto, Fabrizio Capuani
The FIRC Institute for Molecular Oncology, Milan, Italy
John J Tyson
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Corresponding Author

Email: andrea.ciliberto@ifom-ieo-campus.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AC and JJT conceived and designed the experiments and wrote the report. AC and FC performed the experiments and analyzed the data.