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Research Article

A Look Inside HIV Resistance through Retroviral Protease Interaction Maps

  • Aleksejs Kontijevskis,

    Affiliations: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

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  • Peteris Prusis,

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Ramona Petrovska,

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Sviatlana Yahorava,

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Felikss Mutulis,

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Ilze Mutule,

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Jan Komorowski,

    Affiliation: Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

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  • Jarl E. S Wikberg mail

    To whom correspondence should be addressed. E-mail: Jarl.Wikberg@farmbio.uu.se

    Affiliation: Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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  • Published: March 09, 2007
  • DOI: 10.1371/journal.pcbi.0030048

About the Authors

Aleksejs Kontijevskis, Peteris Prusis, Ramona Petrovska, Sviatlana Yahorava, Felikss Mutulis, Ilze Mutule, Jarl E. S Wikberg
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Aleksejs Kontijevskis, Jan Komorowski
Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

Corresponding Author

Email: Jarl.Wikberg@farmbio.uu.se

Competing Interests

JESW declares financial interest in Genetta Soft, a Swedish incorporated company developing chemo- and bioinformatics software.

Author Contributions

AK and JESW conceived and designed the experiments. RP, SY, FM, and IM performed synthesis and the cleavage assay experiments. AK collected and analyzed the data. AK, PP, JK, and JESW contributed materials/analysis tools. AK, RP, SY, FM, and JESW wrote the paper.