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Research Article

The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

  • Haiyuan Yu equal contributor,

    equal contributor Contributed equally to this work with: Haiyuan Yu, Philip M Kim

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Philip M Kim equal contributor,

    equal contributor Contributed equally to this work with: Haiyuan Yu, Philip M Kim

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Emmett Sprecher,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

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  • Valery Trifonov,

    Affiliation: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Mark Gerstein mail

    To whom correspondence should be addressed. E-mail: Mark.Gerstein@yale.edu

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Published: April 20, 2007
  • DOI: 10.1371/journal.pcbi.0030059

About the Authors

Haiyuan Yu, Philip M Kim, Emmett Sprecher, Mark Gerstein
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Haiyuan Yu
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Haiyuan Yu
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Emmett Sprecher, Mark Gerstein
Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America
Valery Trifonov, Mark Gerstein
Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

Corresponding Author

Email: Mark.Gerstein@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HY, PMK, and MG conceived and designed the experiments and wrote the paper. HY, PMK, and VT performed the experiments. HY, PMK, and ES analyzed the data. HY and MG contributed reagents/materials/analysis tools.