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Research Article

Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network

  • Matteo Barberis equal contributor,

    equal contributor Contributed equally to this work with: Matteo Barberis, Edda Klipp

    Affiliations: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy, Max-Planck Institute for Molecular Genetics, Computational Systems Biology, Berlin, Germany

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  • Edda Klipp equal contributor mail,

    equal contributor Contributed equally to this work with: Matteo Barberis, Edda Klipp

    To whom correspondence should be addressed. E-mail: klipp@molgen.mpg.de (EK); lilia.alberghina@unimib.it (LA)

    Affiliation: Max-Planck Institute for Molecular Genetics, Computational Systems Biology, Berlin, Germany

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  • Marco Vanoni,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Lilia Alberghina mail

    To whom correspondence should be addressed. E-mail: klipp@molgen.mpg.de (EK); lilia.alberghina@unimib.it (LA)

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Published: April 13, 2007
  • DOI: 10.1371/journal.pcbi.0030064

About the Authors

Matteo Barberis, Marco Vanoni, Lilia Alberghina
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Matteo Barberis, Edda Klipp
Max-Planck Institute for Molecular Genetics, Computational Systems Biology, Berlin, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MB data-mined the literature, designed the structure of the mathematical model, and performed the simulations. EK provided modeling experience and mathematical model implementation. LA data-mined the literature and conceived the structure of the model. MB, EK, and LA planned simulation experiments. MB, MV, and LA evaluated biological significance. MB EK, MV, and LA wrote the paper.