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Research Article

Regulatory Circuit of Human MicroRNA Biogenesis

  • Ji Lee,

    Affiliations: Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Zhihua Li,

    Affiliation: Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Rachel Brower-Sinning,

    Affiliation: Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Bino John mail

    To whom correspondence should be addressed. E-mail: john@johnlab.org

    Affiliations: Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America

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  • Published: April 20, 2007
  • DOI: 10.1371/journal.pcbi.0030067

About the Authors

Ji Lee, Zhihua Li, Rachel Brower-Sinning, Bino John
Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Ji Lee
Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, United States of America
Bino John
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: john@johnlab.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JL implemented the K-Factor algorithm in Java, generated results, and contributed to writing the manuscript. ZL analyzed the core results and computationally identified specific CRMs. RBS was involved in benchmarking the performance of K-Factor. BJ conceived the project, designed and implemented the underlying methods and datasets, generated results, wrote the manuscript, and supervised the project.