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Research Article

Increasing the Power to Detect Causal Associations by Combining Genotypic and Expression Data in Segregating Populations

  • Jun Zhu equal contributor,

    equal contributor Contributed equally to this work with: Jun Zhu, Matthew C Wiener, Chunsheng Zhang, Arthur Fridman

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Matthew C Wiener equal contributor,

    equal contributor Contributed equally to this work with: Jun Zhu, Matthew C Wiener, Chunsheng Zhang, Arthur Fridman

    Affiliation: Department of Applied Computer Science and Mathematics, Merck Research Laboratories, Rahway, New Jersey, United States of America

    X
  • Chunsheng Zhang equal contributor,

    equal contributor Contributed equally to this work with: Jun Zhu, Matthew C Wiener, Chunsheng Zhang, Arthur Fridman

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Arthur Fridman equal contributor,

    equal contributor Contributed equally to this work with: Jun Zhu, Matthew C Wiener, Chunsheng Zhang, Arthur Fridman

    Affiliation: Department of Applied Computer Science and Mathematics, Merck Research Laboratories, Rahway, New Jersey, United States of America

    X
  • Eric Minch,

    Affiliation: Department of Applied Computer Science and Mathematics, Merck Research Laboratories, Rahway, New Jersey, United States of America

    X
  • Pek Y Lum,

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Jeffrey R Sachs,

    Affiliation: Department of Applied Computer Science and Mathematics, Merck Research Laboratories, Rahway, New Jersey, United States of America

    X
  • Eric E Schadt mail

    To whom correspondence should be addressed. E-mail: Eric_Schadt@merck.com

    Affiliation: Rosetta Inpharmatics, Seattle, Washington, United States of America

    X
  • Published: April 13, 2007
  • DOI: 10.1371/journal.pcbi.0030069

About the Authors

Jun Zhu, Chunsheng Zhang, Pek Y Lum, Eric E Schadt
Rosetta Inpharmatics, Seattle, Washington, United States of America
Matthew C Wiener, Arthur Fridman, Eric Minch, Jeffrey R Sachs
Department of Applied Computer Science and Mathematics, Merck Research Laboratories, Rahway, New Jersey, United States of America

Corresponding Author

Email: Eric_Schadt@merck.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JZ, MCW, CZ, AF, EM, PYL, JRS, and EES conceived the idea. JZ, CZ, AF, and JRS designed the simulation. MCW, AF, EM, and JRS designed the evaluation. JZ, AF, CZ, and JRS were responsible for genetic and gene expression data simulation. JZ, CZ, and AF were responsible for network reconstruction. PYL and JRS coordinated the project. All authors contributed to writing the paper.