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Research Article

Patterns of Mesenchymal Condensation in a Multiscale, Discrete Stochastic Model

  • Scott Christley,

    Affiliations: Department of Computer Science, University of Notre Dame, Notre Dame, Indiana, United States of America, Interdisciplinary Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, Indiana, United States of America

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  • Mark S Alber mail,

    To whom correspondence should be addressed. E-mail: malber@nd.edu (MSA); newman@nymc.edu (SAN)

    Affiliations: Interdisciplinary Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, Indiana, United States of America, Department of Mathematics, University of Notre Dame, Notre Dame, Indiana, United States of America

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  • Stuart A Newman mail

    To whom correspondence should be addressed. E-mail: malber@nd.edu (MSA); newman@nymc.edu (SAN)

    Affiliation: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, United States of America

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  • Published: April 27, 2007
  • DOI: 10.1371/journal.pcbi.0030076

About the Authors

Scott Christley
Department of Computer Science, University of Notre Dame, Notre Dame, Indiana, United States of America
Scott Christley, Mark S Alber
Interdisciplinary Center for the Study of Biocomplexity, University of Notre Dame, Notre Dame, Indiana, United States of America
Mark S Alber
Department of Mathematics, University of Notre Dame, Notre Dame, Indiana, United States of America
Stuart A Newman
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SAN formulated the biological questions, provided the in vitro data and, with MA, designed the multipixel, multiscale, quasi–3-D representation. MA and SC designed the discrete stochastic model. SC performed the simulations and, with SAN and MA, interpreted the results. SC, MA, and SAN wrote the paper.