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Research Article

Ligand Binding and Circular Permutation Modify Residue Interaction Network in DHFR

  • Zengjian Hu,

    Affiliation: Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America

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  • Donnell Bowen,

    Affiliation: Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America

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  • William M Southerland mail,

    To whom correspondence should be addressed. E-mail: wsoutherland@howard.edu (WMS); mab@ncifcrf.gov (BM)

    Affiliation: Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America

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  • Antonio del Sol,

    Affiliation: Bioinformatics Research Project, Research and Development Division, Fujirebio, Tokyo, Japan

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  • Yongping Pan,

    Affiliation: Basic Research Program, Science Applications International Corporation—Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute—Frederick, Frederick, Maryland, United States of America

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  • Ruth Nussinov,

    Affiliations: Basic Research Program, Science Applications International Corporation—Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute—Frederick, Frederick, Maryland, United States of America, Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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  • Buyong Ma mail

    To whom correspondence should be addressed. E-mail: wsoutherland@howard.edu (WMS); mab@ncifcrf.gov (BM)

    Affiliation: Basic Research Program, Science Applications International Corporation—Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute—Frederick, Frederick, Maryland, United States of America

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  • Published: June 15, 2007
  • DOI: 10.1371/journal.pcbi.0030117

About the Authors

Zengjian Hu, Donnell Bowen, William M Southerland
Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America
Antonio del Sol
Bioinformatics Research Project, Research and Development Division, Fujirebio, Tokyo, Japan
Yongping Pan, Ruth Nussinov, Buyong Ma
Basic Research Program, Science Applications International Corporation—Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute—Frederick, Frederick, Maryland, United States of America
Ruth Nussinov
Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BM conceived and designed the experiments. ZH, DB, WMS, and YP performed the experiments. ZH and BM analyzed the data. AdS, RN, and BM wrote the paper.