About the Authors

Zizhen Yao

To whom correspondence should be addressed. E-mail: yzizhen@cs.washington.edu

Affiliation Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America

Jeffrey Barrick

¤ Current address: Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Zasha Weinberg

Affiliation Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

Shane Neph

Affiliations Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America , Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Ronald Breaker

Affiliations Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America , Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America , Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America

Martin Tompa

Affiliations Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America , Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Walter L Ruzzo

Affiliations Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America , Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ZY, JB, ZW, RB, MT, and WLR conceived and designed the experiments. ZY and ZW performed the experiments. ZY and JB analyzed the data. SN contributed reagents/materials/analysis tools. ZY, JB, and WLR wrote the paper.