A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

Konstantin B Zeldovich; Peiqiu Chen; Boris E Shakhnovich; Eugene I Shakhnovich

doi:10.1371/journal.pcbi.0030139

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Open Access

Peer-reviewed

Research Article

A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

Konstantin B Zeldovich,

Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Peiqiu Chen,

Affiliations Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America , Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Boris E Shakhnovich,

Affiliation Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Eugene I Shakhnovich

*To whom correspondence should be addressed. E-mail: eugene@belok.harvard.edu

Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯

A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

Konstantin B Zeldovich,
Peiqiu Chen,
Boris E Shakhnovich,
Eugene I Shakhnovich

Published: July 13, 2007
https://doi.org/10.1371/journal.pcbi.0030139

About the Authors

Konstantin B Zeldovich

Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

Peiqiu Chen

Affiliations Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America , Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America

Boris E Shakhnovich

Affiliation Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Eugene I Shakhnovich

*To whom correspondence should be addressed. E-mail: eugene@belok.harvard.edu

Affiliation Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KBZ and EIS conceived and designed the experiments and wrote the paper. KBZ performed the experiments. KBZ, PC, BES, and EIS analyzed the data. PC and BES contributed reagents/materials/analysis tools.

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Molecular evolution
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Organismal evolution
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Genomics
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Evolutionary genetics
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Point mutation
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Protein folding
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Structural genomics
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Protein structure
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