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Research Article

On State-Space Reduction in Multi-Strain Pathogen Models, with an Application to Antigenic Drift in Influenza A

  • Sergey Kryazhimskiy mail,

    To whom correspondence should be addressed. E-mail: skryazhi@princeton.edu

    Affiliation: Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America

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  • Ulf Dieckmann,

    Affiliation: Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria

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  • Simon A Levin,

    Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Jonathan Dushoff

    Affiliations: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America

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  • Published: August 17, 2007
  • DOI: 10.1371/journal.pcbi.0030159

About the Authors

Sergey Kryazhimskiy
Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America
Ulf Dieckmann
Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria
Simon A Levin, Jonathan Dushoff
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Jonathan Dushoff
Fogarty International Center, National Institute of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: skryazhi@princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SK, UD, and JD designed the model. SK wrote the code. SK, UD, SAL, and JD wrote the paper.