About the Authors

Julio Saez-Rodriguez

Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Luca Simeoni

Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

Jonathan A Lindquist

Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

Rebecca Hemenway

Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Ursula Bommhardt

Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

Boerge Arndt

Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

Utz-Uwe Haus

Affiliation Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany

Robert Weismantel

Affiliation Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany

Ernst D Gilles

Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Steffen Klamt

To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de

Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Burkhart Schraven

To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de

Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JSR set up the model and performed the analysis. LS, JAL, UB, BA, and BS, with the help of the signaling group at the Institute of Immunology, gathered the biological details of the model and analyzed the correctness of the results. LS and BA performed the wet-lab experiments. RH supported the model setup, analysis, and documentation. SK developed the theoretical methods and tools (CellNetAnalyzer) and supported the analysis. UUH and RW contributed to the theoretical methods with useful insights. EDG, BS, and RW coordinated the project.