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Research Article

A Logical Model Provides Insights into T Cell Receptor Signaling

  • Julio Saez-Rodriguez,

    Affiliation: Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

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  • Luca Simeoni,

    Affiliation: Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

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  • Jonathan A Lindquist,

    Affiliation: Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

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  • Rebecca Hemenway,

    Affiliation: Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

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  • Ursula Bommhardt,

    Affiliation: Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

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  • Boerge Arndt,

    Affiliation: Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

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  • Utz-Uwe Haus,

    Affiliation: Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany

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  • Robert Weismantel,

    Affiliation: Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany

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  • Ernst D Gilles,

    Affiliation: Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

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  • Steffen Klamt mail,

    To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de

    Affiliation: Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

    X
  • Burkhart Schraven mail

    To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de

    Affiliation: Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany

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  • Published: August 24, 2007
  • DOI: 10.1371/journal.pcbi.0030163

About the Authors

Julio Saez-Rodriguez, Rebecca Hemenway, Ernst D Gilles, Steffen Klamt
Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
Luca Simeoni, Jonathan A Lindquist, Ursula Bommhardt, Boerge Arndt, Burkhart Schraven
Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
Utz-Uwe Haus, Robert Weismantel
Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JSR set up the model and performed the analysis. LS, JAL, UB, BA, and BS, with the help of the signaling group at the Institute of Immunology, gathered the biological details of the model and analyzed the correctness of the results. LS and BA performed the wet-lab experiments. RH supported the model setup, analysis, and documentation. SK developed the theoretical methods and tools (CellNetAnalyzer) and supported the analysis. UUH and RW contributed to the theoretical methods with useful insights. EDG, BS, and RW coordinated the project.