About the Authors
- Julio Saez-Rodriguez
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Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
- Luca Simeoni
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Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
- Jonathan A Lindquist
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Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
- Rebecca Hemenway
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Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
- Ursula Bommhardt
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Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
- Boerge Arndt
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Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
- Utz-Uwe Haus
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Affiliation Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany
- Robert Weismantel
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Affiliation Institute for Mathematical Optimization, Otto-von-Guericke University, Magdeburg, Germany
- Ernst D Gilles
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Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
- Steffen Klamt
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*To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de
Affiliation Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
- Burkhart Schraven
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*To whom correspondence should be addressed. E-mail: inquiries regarding the mathematical methodology should be addressed to Steffen Klamt, klamt@mpi-magdeburg.mpg.de, and regarding the biological and experimental data to Burkhart Schraven, Burkhart.Schraven@med.ovgu.de
Affiliation Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
JSR set up the model and performed the analysis. LS, JAL, UB, BA, and BS, with the help of the signaling group at the Institute of Immunology, gathered the biological details of the model and analyzed the correctness of the results. LS and BA performed the wet-lab experiments. RH supported the model setup, analysis, and documentation. SK developed the theoretical methods and tools (CellNetAnalyzer) and supported the analysis. UUH and RW contributed to the theoretical methods with useful insights. EDG, BS, and RW coordinated the project.