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Research Article

Characterization of Protein Hubs by Inferring Interacting Motifs from Protein Interactions

  • Ramon Aragues,

    Affiliation: Structural Bioinformatics Lab (GRIB), Universitat Pompeu Fabra-IMIM, Barcelona Research Park of Biomedicine (PRBB), Barcelona, Catalonia, Spain

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  • Andrej Sali,

    Affiliations: Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America

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  • Jaume Bonet,

    Affiliation: Structural Bioinformatics Lab (GRIB), Universitat Pompeu Fabra-IMIM, Barcelona Research Park of Biomedicine (PRBB), Barcelona, Catalonia, Spain

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  • Marc A Marti-Renom mail,

    To whom correspondence should be addressed. E-mail: mmarti@cipf.es (MAMR); boliva@imim.es (BO)

    Affiliation: Structural Genomics Unit, Bioinformatics Department, Centro de Investigación Príncipe Felipe, Valencia, Spain

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  • Baldo Oliva mail

    To whom correspondence should be addressed. E-mail: mmarti@cipf.es (MAMR); boliva@imim.es (BO)

    Affiliation: Structural Bioinformatics Lab (GRIB), Universitat Pompeu Fabra-IMIM, Barcelona Research Park of Biomedicine (PRBB), Barcelona, Catalonia, Spain

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  • Published: September 14, 2007
  • DOI: 10.1371/journal.pcbi.0030178

About the Authors

Ramon Aragues, Jaume Bonet, Baldo Oliva
Structural Bioinformatics Lab (GRIB), Universitat Pompeu Fabra-IMIM, Barcelona Research Park of Biomedicine (PRBB), Barcelona, Catalonia, Spain
Andrej Sali
Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America
Andrej Sali
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Andrej Sali
California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America
Marc A Marti-Renom
Structural Genomics Unit, Bioinformatics Department, Centro de Investigación Príncipe Felipe, Valencia, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RA conceived of the idea and performed research. AS, MAMR, and BO provided scientific guidance. JB contributed sections to the manuscript. RA, MAMR, JB, and BO analyzed results; RA, AS, MAMR, and BO wrote the paper.