Advertisement
Research Article

Structure-Templated Predictions of Novel Protein Interactions from Sequence Information

  • Doron Betel mail,

    To whom correspondence should be addressed. E-mail: betel@cbio.mskcc.org

    Affiliations: Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    ¤ Current address: Computational and Systems Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Kevin E Breitkreuz,

    Affiliation: Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada

    X
  • Ruth Isserlin,

    Affiliations: Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    X
  • Danielle Dewar-Darch,

    Affiliation: Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada

    X
  • Mike Tyers,

    Affiliations: Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

    X
  • Christopher W. V Hogue

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    X
  • Published: September 21, 2007
  • DOI: 10.1371/journal.pcbi.0030182

About the Authors

Doron Betel, Kevin E Breitkreuz, Ruth Isserlin, Danielle Dewar-Darch, Mike Tyers
Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada
Doron Betel, Ruth Isserlin, Christopher W. V Hogue
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Mike Tyers
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: betel@cbio.mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DB and MT conceived and designed the experiments and wrote the paper. KEB and DDD performed the experiments. DB and RI analyzed the data. RI contributed reagents/materials/analysis tools. DB conceived and designed the project, and performed the computational work. MT and CWVH directed the study.