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Research Article

Universally Sloppy Parameter Sensitivities in Systems Biology Models

  • Ryan N Gutenkunst mail,

    To whom correspondence should be addressed. E-mail: rng7@cornell.edu

    Affiliation: Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York, United States of America

    X
  • Joshua J Waterfall,

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

    X
  • Fergal P Casey,

    Affiliation: UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland

    X
  • Kevin S Brown,

    Affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

    X
  • Christopher R Myers,

    Affiliation: Cornell Theory Center, Cornell University, Ithaca, New York, United States of America

    X
  • James P Sethna

    Affiliation: Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York, United States of America

    X
  • Published: October 05, 2007
  • DOI: 10.1371/journal.pcbi.0030189

About the Authors

Ryan N Gutenkunst, James P Sethna
Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York, United States of America
Joshua J Waterfall
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
Fergal P Casey
UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland
Kevin S Brown
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
Christopher R Myers
Cornell Theory Center, Cornell University, Ithaca, New York, United States of America

Corresponding Author

Email: rng7@cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments. RNG performed the experiments, analyzed the data, and wrote the paper. RNG, JJW, FPC, and CRM contributed reagents/materials/analysis tools.