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Research Article

Construction, Visualisation, and Clustering of Transcription Networks from Microarray Expression Data

  • Tom C Freeman mail,

    To whom correspondence should be addressed. E-mail: tfreeman@staffmail.ed.ac.uk (TCF); aje@sanger.ac.uk (AJE)

    Affiliations: Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Leon Goldovsky,

    Affiliation: European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

    ¤ Current address: Computational Biology Unit, Center for Research and Technology Hellas, Thessaloniki, Greece

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  • Markus Brosch,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Stijn van Dongen,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Pierre Mazière,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Russell J Grocock,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Shiri Freilich,

    Affiliation: European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

    ¤ Current address: Computational Biology Unit, Center for Research and Technology Hellas, Thessaloniki, Greece

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  • Janet Thornton,

    Affiliation: European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

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  • Anton J Enright mail

    To whom correspondence should be addressed. E-mail: tfreeman@staffmail.ed.ac.uk (TCF); aje@sanger.ac.uk (AJE)

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Published: October 26, 2007
  • DOI: 10.1371/journal.pcbi.0030206

About the Authors

Tom C Freeman
Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom
Tom C Freeman, Markus Brosch, Stijn van Dongen, Pierre Mazière, Russell J Grocock, Anton J Enright
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Leon Goldovsky, Shiri Freilich, Janet Thornton
European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TCF and AJE conceived and designed the experiments and wrote the paper. TCF, LG, SvD, and AJE performed the experiments. All authors analyzed the data. TCF, LG, MB, SvD, SF, JT, and AJE contributed reagents/materials/analysis tools.