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Research Article

Stochastic Noise and Synchronisation during Dictyostelium Aggregation Make cAMP Oscillations Robust

  • Jongrae Kim mail,

    To whom correspondence should be addressed. E-mail: jkim@aero.gla.ac.uk

    Affiliations: Control and Instrumentation Group, Department of Engineering, University of Leicester, Leicester, United Kingdom, Systems Biology Laboratory, University of Leicester, Leicester, United Kingdom

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  • Pat Heslop-Harrison,

    Affiliations: Systems Biology Laboratory, University of Leicester, Leicester, United Kingdom, Department of Biology, University of Leicester, Leicester, United Kingdom

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  • Ian Postlethwaite,

    Affiliations: Control and Instrumentation Group, Department of Engineering, University of Leicester, Leicester, United Kingdom, Systems Biology Laboratory, University of Leicester, Leicester, United Kingdom

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  • Declan G Bates

    Affiliations: Control and Instrumentation Group, Department of Engineering, University of Leicester, Leicester, United Kingdom, Systems Biology Laboratory, University of Leicester, Leicester, United Kingdom

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  • Published: November 09, 2007
  • DOI: 10.1371/journal.pcbi.0030218

About the Authors

Jongrae Kim, Ian Postlethwaite, Declan G Bates
Control and Instrumentation Group, Department of Engineering, University of Leicester, Leicester, United Kingdom
Jongrae Kim, Pat Heslop-Harrison, Ian Postlethwaite, Declan G Bates
Systems Biology Laboratory, University of Leicester, Leicester, United Kingdom
Pat Heslop-Harrison
Department of Biology, University of Leicester, Leicester, United Kingdom

Corresponding Author

Email: jkim@aero.gla.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JK and DGB conceived the initial idea for the study. JK designed and performed the numerical experiments. IP checked the mathematical derivations. DGB and PHH provided biological interpretations of the results. All authors contributed to writing the paper.