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Research Article

A Universal Mechanism Ties Genotype to Phenotype in Trinucleotide Diseases

  • Shai Kaplan,

    Affiliations: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

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  • Shalev Itzkovitz,

    Affiliations: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

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  • Ehud Shapiro mail

    To whom correspondence should be addressed. E-mail: ehud.shapiro@weizmann.ac.il

    Affiliations: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel, Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

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  • Published: November 23, 2007
  • DOI: 10.1371/journal.pcbi.0030235

About the Authors

Shai Kaplan, Shalev Itzkovitz, Ehud Shapiro
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Shai Kaplan
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Shalev Itzkovitz, Ehud Shapiro
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

Corresponding Author

Email: ehud.shapiro@weizmann.ac.il

Competing Interests

Weizmann Institute of Science may file a patent based on this work.

Author Contributions

SK and ES conceived and designed the experiments and wrote the paper. All authors analyzed the data and contributed reagents/materials/analysis tools.