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Research Article

The Per2 Negative Feedback Loop Sets the Period in the Mammalian Circadian Clock Mechanism

  • A. Katharina Wilkins,

    Affiliations: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Paul I Barton,

    Affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Bruce Tidor mail

    To whom correspondence should be addressed. E-mail: tidor@mit.edu

    Affiliations: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: December 14, 2007
  • DOI: 10.1371/journal.pcbi.0030242

About the Authors

A. Katharina Wilkins, Paul I Barton
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
A. Katharina Wilkins, Bruce Tidor
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Bruce Tidor
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Bruce Tidor
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: tidor@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments and wrote the paper. AKW performed the experiments and analyzed the data.