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Research Article

Direct Inference of SNP Heterozygosity Rates and Resolution of LOH Detection

  • Xiaohong Li mail,

    To whom correspondence should be addressed. E-mail: xili@fhcrc.org

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Steven G Self,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Patricia C Galipeau,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Thomas G Paulson,

    Affiliations: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Brian J Reid

    Affiliations: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Published: November 30, 2007
  • DOI: 10.1371/journal.pcbi.0030244

About the Authors

Xiaohong Li, Steven G Self, Thomas G Paulson, Brian J Reid
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Patricia C Galipeau, Thomas G Paulson, Brian J Reid
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Brian J Reid
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Brian J Reid
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: xili@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XL, SGS, PCG, TGP, and BJR conceived and designed the experiments, and performed the experiments. XL analyzed the data. XL contributed reagents/materials/analysis tools. XL, SGS, PCG, TGP, and BJR wrote the paper.